Monoclonal antibody against brain natriuretic peptide and characterization of brain natriuretic peptide-transgenic mice

ObjectiveBrain natriuretic peptide (BNP) is a ventricular hormone with natriuretic, diuretic and vasodilatory actions. Acute infusion of BNP reduces cardiac pre- and after-load in healthy and diseased subjects, but its long-term therapeutic usefulness remains unclear.DesignWe prepared a monoclonal a