The association of BRCA1 and BRCA2 mutations on prostate cancer risk, frequency, and mortality: Systematic review and meta-analysis.

5060Background: A prior meta-analysis (Fachal, Prostate, 2011) suggested no association between BRCA1 mutation and prostate cancer (PCa). Several additional BRCA2 studies have shown an association with PCa risk and mortality. We conducted a systematic review and meta-analysis of BRCA1 and BRCA2 studies to estimate PCa risk in BRCA mutation carriers, evaluate the frequency of BRCA mutation carriers in PCa patients (pts) and compare survival rate among BRCA mutation carriers and non-carriers. Methods: PubMed/MEDLINE, Embase and Cochrane databases were searched for relevant studies for the above objectives. Meta-analyses were conducted using unadjusted odds ratio (OR) with 95% confidence interval (95%CI) for PCa incidence; frequency (%) of BRCA mutation in PCa pts; and hazard ratio (HR) with 95%CI for cancer-specific survival (CSS) and overall survival (OS). Random effects analyses were performed for overall BRCA (BRCA1 or BRCA2), with subgroup analyses for BRCA1 and BRCA2 separately. Results: 10 cohort, 10 ...