Dexamethasone Inner Ear Perfusion by Intratympanic Injection in Unilateral Ménière's Disease: A Two-year Prospective, Placebo-Controlled, Double-blind, Randomized Trial:

Objective:To investigate the efficacy of dexamethasone inner ear perfusion by intratympanic injection in hearing loss, tinnitus, aural fullness, and vertigo in the treatment of unilateral Meniere's disease and compare it with the control group.Study Design and Setting:A prospective, randomized, double-blind study with 2-year follow-up comparing changes secondary to dexamethasone inner ear perfusion versus placebo consisting of saline solution.Patients:Twenty-two patients having definite Meniere's disease as outlined by the 1995 American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium. All the patients were older than 18 years of age and were not receiving any other form of treatment with steroids for their Meniere's disease.Method:Five consecutive daily intratympanic injections of dexamethasone or placebo to the involved ear.Results:In the dexamethasone group at 2-year follow-up, complete control of vertigo (class A) was achieved in 9 of 11 patients (82%) and substanti...