Adherence to recommendations for the use of antifungal agents in a tertiary care hospital

Received 1 December 2011; returned 27 January 2012; revised 22 March 2012; accepted 4 June 2012Objectives: The aim of our study was to assess the adherence to labelling and international guidelines for anti-fungal prescribing.Methods: A retrospective study was performed in intensive care units in addition to the oncology and haema-tology department, which covered 70% of antifungal consumption at Hautepierre Hospital, Strasbourg, France.On reviewing medical charts, the antifungal prescription was examined in relation to the recommendations ofindication, dosage, risk of drug–drug interactions and, where appropriate, antifungal susceptibility testing.Treatments were considered appropriate, inappropriate or debatable.Results: Between January and April 2007, 199 treatments were given for 179 different episodes in 133 adultpatients. Treatments were prescribed for pre-emptive or targeted therapy (n¼90, with 60 for candidiasis, 26 foraspergillosis and 4 for other mould diseases), empirical therapy (n¼17) and primary (n¼81) or secondary(n¼11) prophylaxis. Fluconazole accounted for 67% of prescriptions, followed by voriconazole (19%), caspofun-gin (10%), posaconazole (2%), conventional or liposomal amphotericin B (2%), itraconazole (,1%) and terbina-fine (,1%). Indication and dosage were found to be appropriate in 65% and 62% of cases, inappropriate in22% and 21%, and debatable in 13% and 17%, respectively. The overall (by combining all assessment criteria)rate of inappropriate use was 40%. The overall survival rate at 12 weeks was highest in patients receiving ap-propriate therapy (81% versus 72% and 68% in the debatable and inappropriate therapy groups, respectively),with between-group differences not being significant (P¼0.49).Conclusions: Our evaluation revealed a high proportion of inappropriate or debatable use of antifungal agents,while highlighting significant issues, such as inadequate dosage or indications.Keywords: aspergillosis, candidiasis, guidelines, invasive fungal infections, antifungal therapy