Naproxen α crystal form of Imatinib and its preparation method tosylate and a pharmaceutical composition thereof

The present invention provides a compound N- [4 - [(3- chloro-4-fluorophenyl) amino] -7- [3- (ethoxy) -6-quinazolinyl] -4- (dimethylamino ) -2-butenamide toluenesulfonate over 1.5 hydrate crystalline polymorph [alpha], melting point, chemical stability and stable form having determined high temperature and light, suitable for pharmaceutical use.