Synthesis and anticonvulsant activity of some new pyrazolo[3,4-b]pyrazines and related heterocycles.

Abstract A series of new pyrazolo[3,4- b ]pyrazines containing, 1,2,4-oxadiazolyl, thiadiazolyl, imidazothiadiazolyl, thiazolidinonyl, substituents and other different substituents, was synthesized using 1,6-diphenyl-3-methyl-l H -pyrazolo[3,4- b ]pyrazine-5-carbonitrile ( 2 ) as a starting material. Some of the newly prepared compounds were evaluated for their anticonvulsant activity. Compounds 9a , 13a – d and 14a at a dose of 10 mg/kg showed very significant anticonvulsant activity and increased the latency time of PTZ-induced tonic seizures. Compound 9b showed significant effect.