Immunosuppressive therapy with low cyclosporin A doses in rats

: An optimum blood level of cyclosporine-A (Cs-A) after allotransplantation in rats is very important for the survival of the transplanted organ. An auxiliary allotransplantation of the heart into the abdominal cavity were carried out in 10 rats. A Cs-A blood level of 200 to 300 ng ml was obtained by administration in the animal food in a dosage of 7 mg kg body weight day. A rejection of the graft was prevented in this way without any symptom of toxicity during 90 days. The results of the experiments were well reproducible. The obtained Cs-A blood level is relatively stationary, frequent laboratory tests are not necessary.