GlcNAcylation of histone H2B facilitates its monoubiquitination

Ryoji Fujiki,Waka Hashiba,Hiroki Sekine,Atsushi Yokoyama,Toshihiro Chikanishi,Saya Ito,Yuuki Imai,Jaehoon Kim,Housheng Hansen He,Katsuhide Igarashi,Jun Kanno,Fumiaki Ohtake,Hirochika Kitagawa,Robert G. Roeder,Myles Brown,Shigeaki Kato

GlcNAcylation of histone H2B facilitates its monoubiquitination

2011

Ryoji Fujiki
Waka Hashiba
Hiroki Sekine
Atsushi Yokoyama
Toshihiro Chikanishi
Saya Ito
Yuuki Imai
Jaehoon Kim
Housheng Hansen He
Katsuhide Igarashi
Jun Kanno
Fumiaki Ohtake
Hirochika Kitagawa
Robert G. Roeder
Myles Brown
Shigeaki Kato

Genome-wide analysis shows that H2B S112 O-linked to N-acetylglucosamine is frequently located near transcribed genes, suggesting that histone GlcNAcylation facilitates transcription of the genes.

Keywords:

Histone H2A
Histone H2B
Histone
Monoubiquitination
Histone methyltransferase
Histone H1
Histone code
Transcription (biology)
Genetics
Biology
Transcriptional regulation
Biochemistry

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