The Associations Between Cognitive Prognosis and Kynurenines Are Modified by the Apolipoprotein ε4 Allele Variant in Patients With Dementia

Arne Olav Ervik,Stein-Erik Hafstad Solvang,Jan Erik Nordrehaug,Per Magne Ueland,Øivind Midttun,Audun Skjaerseth Hildre,Adrian McCann,Ottar Nygård,Dag Aarsland,Lasse Melvaer Giil

The Associations Between Cognitive Prognosis and Kynurenines Are Modified by the Apolipoprotein ε4 Allele Variant in Patients With Dementia

2019

Arne Olav Ervik
Stein-Erik Hafstad Solvang
Jan Erik Nordrehaug
Per Magne Ueland
Øivind Midttun
Audun Skjaerseth Hildre
Adrian McCann
Ottar Nygård
Dag Aarsland
Lasse Melvaer Giil

Background:The apolipoprotein E e4 gene variant (APOEe4) confers considerable risk for dementia and affects neuroinflammation, brain metabolism, and synaptic function. The kynurenine pathway (KP) g...

Keywords:

Endocrinology
Neuroinflammation
Apolipoprotein E
Dementia
Kynurenine pathway
Kynurenic acid
Cognition
cognitive decline
Internal medicine
Alzheimer's disease
Medicine
Bioinformatics

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