Are we failing to capture the relationship between body mass index and cardiovascular disease and mortality in subjects with type 2 diabetes

• There is a substantial body of epidemiological evidence relating body-mass index (BMI) to increased risk of cardiovascular disease and all-cause mortality (ACM) in subjects with type-2 diabetes mellitus (T2DM)[1,2]. • Cardiovascular (CV) and mortality risk equations typically incorporate the effects of elevated BMI via the inter-relationship between modifiable CV risk factors (such as cholesterol and systolic blood pressure) and BMI; this approach may underestimate true mortality risk. • Accurate prediction of the long-term health consequences associated with the management of T2DM is crucial if the value of new health technologies that promote weight loss are to be fully captured. • Therefore, the objective of this study was to assess by how much existing risk equations underestimate the risk of mortality as a function of increasing levels of BMI. Objectives