Efficacy of ubenimex combined with MPT on multiple myeloma patients who are unwilling to receive intravenous chemotherapy

Objective To investigate the effect and immune function of ubenimex in the treatment of middle-aged and aged patients with multiple myeloma who were unwilling to receive intravenous chemotherapy.Methods Patients were divided into two groups randomly,control group applied MPT scheme,treatment group applied MPT and ubenimex.Efficacy and T cell subgroup were evaluated after two cycles.Results Both group of CD4 + T cell percentage were lower after treatment than before treatment,CD8 + T cell percentage were higher after treatment than before treatment,the differences were statistically significant.There was no significant difference between the two groups before and after treatment.The effective rate of treatment group was higher than that of control group,the difference was statistically significant.Conclusions Ubenimex combined with chemotherapy can improve the treatment efficiency. Key words: Ubenimex;  The middle-aged and older;  Multiple myeloma;  Immune function