Venous Thromboembolism in Surgical Lung Cancer Patients: A Provincial Population-Based Study.

Abstract Background Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in surgical patients. Thoracic surgery patients are at increased risk due to inherent technical and disease-specific factors. Other surgical specialties have adopted post-discharge extended VTE prophylaxis; however, evidence is scarce in thoracic surgery. This study aims to identify VTE risk factors and associated mortality among surgical lung cancer patients. Methods Using administrative databases, all patients in the province of Ontario undergoing lung cancer surgery from 2007 to 2017 were identified. Logistic regression identified VTE risk factors at 90-days and one-year postoperatively. A flexible parametric survival analysis compared mortality and survival up to 5 years after surgery between patients with and without VTE. Results Of 65,513 patients diagnosed with lung cancer, 12,626 (19.3%) underwent surgery. VTE incidence at 90-days and 1-year postoperatively was 1.3% and 2.7%, respectively. Open and more extensive resections carried an increased VTE-risk, with pneumonectomy conferring the highest risk (OR = 2.36; p Conclusions Patients undergoing pneumonectomy and those with advanced stage have an increased VTE-risk. Patients suffering a thrombotic complication have an increased risk of mortality, and decreased 5-year survival. Accordingly, strategies to reduce VTE risk should be considered in patients undergoing high risk operations to reduce the mortality of VTEs.