Effects of dexmedetomidine on sevoflurane MAC and postoperative agitation in pediatric laparoscopic surgery inhalation anesthesia

Objective To investigate the effects of dexmedetomidine on sevoflurane MAC and postoperative agitation in pediatric laparoscopic surgery inhalation anesthesia.Methods 60 cases for laparoscopic inguinal hernia surgery in children,were divided with double-blind way into observation group and control group (n=30).Observation group was given infusion Dex 0.4 μ g/kg,in over 10 mins,and then used continuous infusion Dex 0.4 μ g/(kg · h); while the control group received the same volume of 0.9％ sodium chloride solution at the same time infusion,continuous infusion,such as capacity and 0.9％ of sodium chloride solution.Intraoperative anesthesia was maintained with sevoflurane depth Bis 45-55,we observed the sevoflurane MAC values,children awake extubation time and postoperative restlessness occurrence in two groups.Results Under the same depth of anesthesia (Bis 45-55),the observation group s maintaining the MAC sevoflurane inhalation (1.9 ± 0.3) was lower compared with that of the control group (2.2 ± 0.4),the difference was statistically significant (t=3.29,P ＜ 0.01); restlessness occurrence rate of the observation group (6.7％) was lower than that of the control group (26.7％),the difference was statistically significant (x2=4.32,P ＜ 0.05); recovery time of the two groups showed no statistical significant difference [(10.4 ± 2.5),(9.7 ± 2.0),t=1.20,P ＞ 0.05].Conclusion Dex used in inhalation anesthesia for pediatric laparoscopic surgery,can effectively reduce the sevoflurane MAC value,reduce its dosage and the incidence of postoperative agitation in children. Key words: Dexmedetomidine;  Laparoscopic surgery;  Inhalation concentration;  Sevoflurane;  Minimum alveolar concentration;  Postoperative agitation;  Children