Prophylactic therapeutic agent for pulmonary hypertension comprising as an active ingredient a thrombin receptor antagonist

The present invention has an object to provide a pulmonary hypertension therapeutic agent or prophylactic agent. The present invention relates to compounds of the general formula containing a compound or a pharmaceutically acceptable salt or a hydrate thereof having a PAR1 inhibition, such as 2-iminopyrrolidine derivative represented by the formula (I), pulmonary hypertension to therapeutic or prophylactic agent.