Novel neurotrophic phenylbutenoids from Indonesian ginger Bangle, Zingiber purpureum.

Abstract Two new curcuminoids 1 and 2 , and a new phenylbutenoid dimer 3 , were isolated from Bangle ( Zingiber purpureum ). Their structures were determined on the basis of comprehensive spectroscopic data and their biogenetic pathway. Compounds 1 and 2 are the first example of curcumin coupled with phenylbutenoid. Compounds 1 and 2 promoted neurite outgrowth of NGF-mediated PC12 cells at concentrations ranging from 1 to 10 μM. In addition, compound 1 was found to accelerate the prevention of Aβ42 aggregation.