Стандартные образцы в медико-биологических исследованиях

The paper represents general information of use of reference material (RM) of composition of toxic metal solutions and RM of composition of biological tissues which contain toxic metals (TM) when measuring the TM content in biological materials. The paper describes and analyses the approaches for preparing samples of reference materials which contain Pb, Hg, Cd, Be and TI, developed by the Institute of Toxicology Federal Bio-Medical Agency of Russia and Ural Research Institute for Metrology. When developing, approving and certification of the relevant measurement methods for TM content in biological materials it is necessary to include, as an essential condition, the requirement to use RM of composition of biological tissues which analyte is naturally built in the material matrix as a result of metabolic process. The analogical requirement should be produced when accrediting and licensing medical and biological laboratories and laboratories of chemical and analytical control.