Functional ATP-Binding Cassette Drug Efflux Transporters in Isolated Human and Rat Hepatocytes Significantly Affect Assessment of Drug Disposition

Patrik Lundquist,Gunilla Sandborgh Englund,Cristine Skogastierna,Johan Lööf,Jenny Johansson,Janet Hoogstraate,Lovisa Afzelius,Tommy Andersson

Functional ATP-Binding Cassette Drug Efflux Transporters in Isolated Human and Rat Hepatocytes Significantly Affect Assessment of Drug Disposition

2014

Patrik Lundquist
Gunilla Sandborgh Englund
Cristine Skogastierna
Johan Lööf
Jenny Johansson
Janet Hoogstraate
Lovisa Afzelius
Tommy Andersson

Freshly isolated hepatocytes are considered the gold standard for in vitro studies of hepatic drug disposition. To ensure a reliable supply of cells, cryopreserved human hepatocytes are often used. ...

Keywords:

Biochemistry
Drug
ATP-binding cassette transporter
Chemistry
Pharmacology
In vitro
Efflux
Transporter
Drug disposition
efflux transporters

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