CuI催化的酚与富电子对溴苯甲醚和缺电子间溴苯甲醚的 O- 芳基化反应研究

CuI-catalyzed O-arylation of phenols with electron-rich 4-bromoanisole and electron-deficient 3-bromoanisole was described. Electron-deficient 3-bromoanisole showed high reactivity, and electron-rich 4-bromoanisole had low reactivity. O-Arylation of 4-bromoanisole occurred to afford the product by increasing reaction temperature and time. This reaction was applied to the synthesis of 1-chloro-4-(4-methoxyphenoxy)benzene, which was further synthesized to herbicide Clofop. Keywords cross-coupling; electron-rich; electron-deficient; CuI-catalyzed; O-arylation