The relationship between different dosages of mannitol 20% and osmolarity, blood sugar serum, and coagulation factors in moderate brain injury patients with increased intracranial pressure

Abstract Objective Traumatic brain injuries have high mortality rates in many countries. Chemical parameters such as blood osmolarity, serum blood sugar, and coagulation factors can be used to assess the prognosis of a brain injury. Increased intracranial pressure and swelling of the brain are clinical manifestations of brain injury. One option for non-operative treatment is the use of mannitol (MT). This research aims to determine the dosage of MT 20% that demonstrates better levels of safety and effectiveness, based on the evaluation of 3 laboratory-test parameters. Method This research is a prospective cohort with a total sample of 30 patients with moderate brain injuries, who are divided randomly into two groups of different dosages of MT. Results The results are analyzed using repeated measures ANOVA tests and are significant if p   0.05). Conclusion MT 20% does not affect blood osmolarity, serum blood sugar, and coagulation factors.