The effect of Genetic Cancer Risk Assessment (GCRA) on the uptake of risk-reducing surgeries (RRS) in Hispanic women with breast cancer (BC).

1548Background: The management of women with BC includes GCRA for those at risk of carrying deleterious BRCA mutations. GCRA can aid decisions regarding RRS, including contralateral risk reducing mastectomy (CRRM) and risk reducing salpingoophorectomy (RRSO). The uptake of RRS among Hispanic women with BC is unknown, partly due to disparities in access to GCRA. We hypothesized that these disparities may be accentuated in Latin America (LA). Methods: Hispanic women from the US & LA (Mexico, Colombia, Peru & Puerto Rico) with history of BC who underwent GCRA, enrolled in the Clinical Cancer Genomics Community Research Network registry from 1997-2016 were included. Demographic characteristics and data regarding RRS were obtained from chart reviews and self-reported surveys. Data was analyzed using Fisher’s and x2 tests. An adjusted logistic regression model including a set of selected factors was used to predict the likelihood of undergoing RRS. Results: RRS data was collected on 1,517 Hispanic women with BC...