Abstract 13010: Endothelin-1 Increases ACVRL-1 Expression at the Transcriptional and Post-transcriptional Levels in Human Pulmonary Arterial Endothelial Cells via Gi, RhoA and Rho Kinase Pathway With Involvement of Sp-1

Koichi Sugimoto,Tetsuro Yokokawa,Tomofumi Misaka,Sayoko Yokokawa,Kazuhiko Nakazato,Takafumi Ishida,Yasuchika Takeishi

Abstract 13010: Endothelin-1 Increases ACVRL-1 Expression at the Transcriptional and Post-transcriptional Levels in Human Pulmonary Arterial Endothelial Cells via Gi, RhoA and Rho Kinase Pathway With Involvement of Sp-1

2020

Koichi Sugimoto
Tetsuro Yokokawa
Tomofumi Misaka
Sayoko Yokokawa
Kazuhiko Nakazato
Takafumi Ishida
Yasuchika Takeishi

Backgrounds: Pulmonary arterial hypertension (PAH) is characterized by pulmonary vasoconstriction and organic stenosis due to abnormal proliferation of pulmonary vascular cells. Endothelin (ET)-1 i...

Keywords:

Endothelium
Endocrinology
Hypoxic pulmonary vasoconstriction
Internal medicine
RHOA
Endothelin 1
Endothelin receptor
Rho-associated protein kinase
Medicine
Pulmonary hypertension
Signal transduction

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