Progress on the regulation of basic elements of NF-кB signaling pathway

The nuclear factor-kappaB (NF-kappaB) signaling pathway regulates diverse biological proces-ses, including the immune and inflammatory responses, cell growth, apoptosis, and turnout formation. In un-librium state between the cytoplasm and the nucleus, while most of the complexs reside in the cytoplasm. With stimuli from extracell, a serial of kinases are actived and lots of proteins will be oligomerization through from NF-KB, .which active the transcription of target genes. Since a wide range of diseases were found to pathway has been stndied extensively. Key words: NF-кB;  Signal transduction;  Regulation