Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD)

Abstract Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of livestock caused by a highly variable RNA virus, foot-and-mouth disease virus (FMDV). One of the targets to suppress expansion of and to control FMD is 3D polymerase (FMDV 3Dpol). In this study, 2-amino-4-arylthiazole derivatives were synthesized and evaluated for their inhibitory activity against FMDV 3Dpol. Among them, compound 20i exhibited the most potent functional inhibition (IC 50  = 0.39 μM) of FMDV 3D polymerase and compound 24a (EC 50  = 13.09 μM) showed more potent antiviral activity than ribavirin (EC 50  = 1367 μM) and T1105 (EC 50  = 347 μM) with IBRS-2 cells infected by the FMDV O/SKR/2010 strain.