Can folic acid reduce the risk of autism

Introduction: Under the collective name Generalized Violation Of the Autism Spectrum (Autism Spectrum Disorders, ASD) are included several different forms of abnormal neurological development, the most common of which is autism. Over the past 20 years, diagnosed with ASD cases worldwide have increased by 600%. Evidence is accumulated for the etiology of autism. Objective:  The aim of this work is to summarize the data from the on-line scholastic publications which analyze the non-genetic factors in the etiology of autism. Results: In addition to the genetic factor, whose role is proven, also are important a great number of non-genetic factors acting in the perinatal period. They can affect the development of the nervous system of the fetus. Among this group of factors most convincing links are established with the environmental pollution (particulate matter and toxic elements in the air), the prepregnancy overweight of the mother, unhealthy nutritional habits and lack of some essential nutrients at the start of pregnancy. The results show that the periconceptional folic acid intake reduces the risk of having a child with autism by 40%. There is evidence that the lack of n-3 fatty acids affect the onset of symptoms in children with autism. Conclusion: Intervention programs at the periconceptional period, associated whit folate supplementation would be effective strategies for reducing the risk of having a child with autism.