Application value of biological mesh in the pelvic floor reconstruction of extralevator abdominoperineal excision for advanced low rectal cancer
2018
Objective
To investigate the application value of biological mesh in the pelvic floor reconstruction of extralevator abdominoperineal excision (ELAPE) for advanced low rectal cancer (RC).
Methods
The retrospective cohort study was conducted. The clinicopathological data of 228 patients with advanced low RC who underwent ELAPE in the Beijing Chaoyang Hospital of Capital Medical University between August 2008 and December 2016 were collected. Of 228 patients, 174 using biological mesh closure and 54 using primary closure were respectively allocated into the biological mesh group and primary closure group. Observation indicators: (1) intra- and post-operative situations; (2) postoperative complications (including short-term and long-term complications); (3) follow-up and survival situations. Follow-up using outpatient examination and telephone interview was performed to detect postoperative long-term complications, tumor recurrence or metastasis and overall survival up to December, 2017. Measurement data with normal distribution were represented as ±s, and comparison between groups was analyzed using the independent-sample t test. Measurement data with skewed distribution were described as M (range), and comparison between groups was analyzed using the nonparametric test. Comparisons of count data were evaluated by the chi-square test or Fisher exact probability.
Results
(1) Intra- and post-operative situations: all the patients underwent successful ELAPE. The perineal operation time, time of indwelling perineal drainage-tube and hospital expenses were respectively (60±50)minutes, (11.6±2.4)days, (57 781±11 337)yuan in the biological mesh group and (50±21)minutes, (8.9±1.7)days, (53 714±13 395)yuan in the primary closure group, with statistically significant differences between groups (t=3.327, 7.691, -2.203, P 0.05). (2) Postoperative complications: 26 and 19 patients in the biological mesh group and primary closure group had respectively perineal wound complications (1 patient combined with multiple complications), showing a statistically significant difference between groups (χ2=10.660, P 0.05).
Conclusions
The biological mesh in the pelvic floor reconstruction of ELAPE for advanced low RC is safe and feasible. Compared with primary closure, biological mesh closure will extend perineal operation time and time of indwelling perineal drainage-tube, and increase hospital expenses, but doesn′t affect total operation time and duration of postoperative hospital stay, meanwhile, it can also reduce the overall perineal wound complications, especially in perineal wound infection, perineal hernia and disruption of perineal wound.
Key words:
Rectal neoplasms; Extralevator abdominoperineal excision; Biological mesh; Perineal wound healing; Perineal wound complications
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