STUDY ON THE RADIOGOLD PREPARED EXPERIMENTALLY IN JAPAN

Sterilized and pyrogen free gold-198 colloid was produced from irradiated gold foil and was examined biologically and clinically from the viewpoint of practical use. The colloid was prepared by reduction with glucose or ascorbic acid and was adjusted to a gold concentration 10 mg/ml and particle size 3.6 to 9.5 m mu . It was confirmed that the colloid contained no ionic gold, and its half life and radiation energy were practically equal to values reported in literature. Results are presented for the following biological examinations: local deposition, leukocyte numbers, hematological examination, distribution in the mouse, radioautograph, effects on experimental ascites cells, effects on HeLa cells, and the effects on experimental tumor. (N.W.R.)