Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose

The biological active polyurethane (PU) based on diisocyanate prepolymer and folate-lactose (FL) was synthesized. Physical, mechanical and thermophysical properties of polymeric films were investigated. It was found that the value of the strength at break and elongation of PU with FL are higher by 83% and 22% than the corresponding physical and mechanical properties of the PU with D-lactose. According to the obtained results, the characteristic viscosity and water absorption of PU with FL are higher by 44% and 34% for the parameters of PU containing D-lactose. It has been established that prepeared PU are single-phase. The glass transition temperature is 247 K for PU with FL and 245 K for PU with D-lactose. At the same time, FL introduction into the polymer matrix causes decreasion of the heat jump value (ΔСр) to 0,1551 J/g(°C) for PU with FL sample and 0,2911 J/g(°C) for PU with D-lactose sample. Biodegradation of synthesized materials was investigated after incubation in physiological solution (0.9% NaCl) and biological medium 199 for 180 days. According to research results, polyurethane, modified by folate-lactose, retains sufficient performance for use within 6 months in conditions close to the human body. Biological activity and biocompatibility of synthesized polyurethane modified with FL were confirmed by tissue culture and histological methods.