Synthesis and sar of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/tachykinin NK1 receptor antagonist activity

Abstract A series of 4-(1 H -benzimidazole-2-carbonyl)piperidines with dual histamine H 1 /tachykinin NK 1 receptor antagonist activity has been prepared. Factors affecting receptor binding affinities and oral activity in this series are described.