Expeditious Access to Diversely Substituted Indolizines Using a New Multi-component Condensation

Multi-component condensations are among the most powerful tools in the arsenal of the modern medicinal chemist. Herein we disclose a new, highly efficient, three-component synthesis of diversely substituted fused amino-pyrrolo-heterocycles by the condensation of activated methylene compounds, aldehydes and isonitriles.