Experience in the clinical use of intravenous hypnotic pofol (propofol) in anesthesias of different duration

A new anesthetic pofol is characterized by predominantly hypnotic effect; it is a pharmacological analog of a well-known drug diprivan (propofol). The drug was used in 60 anesthesias for bronchoscopic manipulations and cardiosurgical operations. Its effects on hemodynamics, gas exchange, and reactions during induction and after anesthesia were evaluated. The present findings and results of previous clinical trials of diprivan indicate identity of pofol and diprivan. Clinical course of induction and anesthesia and hemodynamic reactions and effects on the respiratory system of patients were virtually the same. Pofol is well tolerated by the patients, its allergenic activity is low, it is rapidly metabolized and causes virtually no side effects. Positive results of clinical trials of pofol recommend it for clinical use.