Exogenous administration of visfatin affects cytokine secretion and increases oxidative stress in human malignant melanoma Me45 cells.

INTRODUCTIONVisfatin has been strongly associated with the systemicinflammation and, to a lesser extent, with the oxidative stress;nevertheless the causal relationships between these factorsremain unclear (1).Data regarding visfatin concentration in people sufferingfrom carcinomas are scarce, however available in the literature(2-4). In healthy subjects, circulating concentration of visfatinare significantly increased in obese subjects (up to 2.5 ng/ml)compared to lean controls (up to 1 ng/ml) according to ELISAassay (5). In other cases, plasma visfatin levels in women withpolycystic ovary syndrome (PCOS) are (30.2 ng/ml ±10.4) whencompared to normal controls (11.2 ng/ml ±10.4) according toRIA assay (6). Zwirska-Korczala