Lack of influence of test meal fatty acid composition on the contribution of intestinally-derived lipoproteins to postprandial lipaemia
1999
The extent and duration of postprandial lipaemia have been linked to risk of CHD but the
influence of dietary variables on, and the relative contributions of, exogenous (chylomicron) and
endogenous (VLDL) triacylglycerols to the total lipaemic response have not been comprehensively
evaluated. In the present study the triacylglycerol, apolipoprotein (apo) B-48 and retinyl
ester (RE) responses to three test meals of varying monounsaturated (MUFA) and saturated fatty
acid (SFA) content were measured in the triacylglycerol-rich lipoprotein (TRL) fraction of
plasma (r ¼ 1·006 g/ml) for 9 h after meal consumption. Fifteen healthy normolipidaemic young
men consumed, on separate occasions, three test meals which were identical apart from their
MUFA and SFA contents. Expressed as a percentage of total energy the MUFA/SFA contents
of the meals were: (1) 12 %/17 %; (2) 17 %/12% and (3) 24 %/5 %. The contribution of the
intestinally-derived lipoproteins (chylomicrons) to the lipaemic response was investigated by
determining the time to reach peak concentration and the total and incremental areas under
the time response curves (AUC and incremental AUC) for RE, apoB-48 and triacylglycerol in the
TRL fraction. No significant differences in these measurements were observed for the three
meals. However, visual comparison of the postprandial responses to the three meals suggested
that as meal MUFA content increased there was a tendency for the triacylglycerol, apoB-48 and
RE responses to become biphasic as opposed to the typical monophasic response seen with the
12% MUFA/17% SFA meal. Comparison of the apoB-48 and RE responses for the three test
meals confirmed other workers’ findings of delayed entry of RE relative to apoB-48 in TRL. The
value of the two markers in investigating dietary fat absorption and metabolism is discussed.
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