THU0399 Female sexual dysfunction in patients with idiopathic inflammatory myopathies

Background Idiopathic inflammatory myopathies (IIM) are characterised by inflammation and atrophy of skeletal muscles, pulmonary and articular involvement, which leads to functional impairment, reduced quality of life including sexual life. Objectives To assess sexual functions/quality of life and pelvic floor function in female IIM patients compared to age-/sex-matched healthy controls (HC). Methods In total, 22 women with IIM [mean age: 55.1, disease duration: 7.9 years, dermatomyositis (DM, 8)/polymyositis (PM, 10)/necrotizing myopathy (IMNM, 3)/inclusion body myositis (IBM, 1)], who fulfilled the Bohan/Peter 1975 criteria for DM/PM, and 22 healthy controls (mean age: 55.1 years) without rheumatic diseases filled in 12 well-established and validated questionnaires assessing sexual function/quality of life, pelvic floor function, fatigue, physical activity and depression. Data are presented as mean ±SEM. Results Compared to HC, patients with IIM had significantly higher prevalence and greater severity of sexual dysfunction (FSFI, BISF-W: in all subscales as well as total scores), dysfunction of pelvic floor (PISQ-12), and worse sexual quality of life (SQoL-F) (table 1). Worse scores in IIM patients were associated with elevated muscle enzyme levels [lactate dehydrogenase: FSFI (r=-0.524,p=0.0123), BISFW (r=-0.528,p=0.0115)], greater fatigue [FIS: FSFI (r=-0.434,p=0.0438), BISF-W (r=-0.488, p=0.0211), SQoL-F (r=-0.488,p=0.0070), PISQ-12 (r=0.643,p=0.0013)], more severe depression [BDI-II: PISQ-12 (r=0.474,p=0,0258)], deteriorated quality of life [HAQ: PISQ-12 (r=0.476,p=0.0252)], and worse ability to perform physical activities [HAP: FSFI (r=0.437,p=0.0417), BISF-W (r=0.451,p=0.0351), PISQ-12 (r=-0.494,p=0.0195)]. Conclusions Women with IIM reported significantly impaired sexual function, sexual quality of life and pelvic floor function than age-matched healthy controls. Worse scores in IIM were associated with disease activity, physical activity, fatigue, depression and quality of life. Acknowledgements Supported by AZV-16–33574A and MHCR 023728. Disclosure of Interest None declared