Reconsiderarea strategiei pentru pacientele cu răspuns ovarian scăzut. Ce ştim acum? La ce ne putem aştepta în viitor?

The strategy for the poor responder patients continues to represent one of the most challenging tasks for the clinicians. The reduced number of follicles reaching advanced stages of folliculogenesis may be due to atresia/cellular mitosis malfunction in the early stages of follicle development (exclusively controlled by paracrine factors) or to endocrine activity issues (especially of gonadotropins) in the final stages of development. Due to its complexity, the reproductive process inevitably entails a wide variety of possible pathologies. The aim of the present study was to review the currently available data on poor responder patients and to anticipate further steps for a better management of this condition.