A Snail1/Notch1 signalling axis controls embryonic vascular development

Notch1 signalling and the dosage of the Notch1 ligand, Dll4, are critical for vascular development. Here the authors show that the transcriptional repressor, Snail1, is expressed in endothelial cells, where it regulates vascular development by downregulating Dll4 levels and Notch1 signalling during mouse embryogenesis.