Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes

Anne Jörns,Tanja Arndt,Andreas Meyer zu Vilsendorf,Jürgen Klempnauer,Dirk Wedekind,Hans-Jürgen Hedrich,Lorella Marselli,Piero Marchetti,Nagakatsu Harada,Yutaka Nakaya,Gen-Sheng Wang,Fraser W. Scott,Conny Gysemans,Chantal Mathieu,Sigurd Lenzen

Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes

2014

Anne Jörns
Tanja Arndt
Andreas Meyer zu Vilsendorf
Jürgen Klempnauer
Dirk Wedekind
Hans-Jürgen Hedrich
Lorella Marselli
Piero Marchetti
Nagakatsu Harada
Yutaka Nakaya
Gen-Sheng Wang
Fraser W. Scott
Conny Gysemans
Chantal Mathieu
Sigurd Lenzen

Aims/hypothesis Research on the pathogenesis of type 1 diabetes relies heavily on good animal models. The aim of this work was to study the translational value of animal models of type 1 diabetes to the human situation.

Keywords:

Beta cell
Biobreeding rat
Type 1 diabetes
Pathogenesis
Immune system
Pancreatic islets
Cytokine
Endocrinology
Immunology
Diabetes mellitus
Biology
Internal medicine
Islet

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