T14, A Non-modulating 150-Kd T Cell Surface Antigen

Monoclonal antibodies to human T lymphocyte surface structures have essentially contributed to a better understanding of cellular mechanisms and interactions involved in the generation of human T cell responses (1). Such antibodies have also proven useful in recent years in the diagnosis of autoimmune, immunodeficiency, and malignant diseases (2). Not surprisingly, monoclonal antibodies to human T lymphocytes are also increasingly used in the treatment of malignant diseases and for selective T cell elimination in bone marrow (3–5) and kidney transplantation (6–8).