Synthesis, molecular docking and cytotoxic study of 7-methoxy-2-(3,4-dimethoxyphenyl)-1-benzofuran-5-carbaldehyde

The 7-methoxy-2-(4-fluorophenyl)-1-benzofuran-5-car baldehyde was synthesized by known literature metho d (Wittig reaction approach) from vanillin. To deduce the anticancer and antibacterial activity of the 7 -methoxy-2-(4fluorophenyl)-1-benzofuran-5-carbaldehyde, it is do cked with different biomarkers of cancer cell and b acteria. Grid was generated for each oncoproteins by specifying t he active site amino acids. The binding model of be st scoring analogue with each protein was assessed from their G-scores and disclosed by docking analysis using th e XP visualizer tool. An analysis of the receptor-ligand interaction studies revealed that 7-methoxy-2-(4-f luorophenyl)-1benzofuran-5-carbaldehyde is most active against 3L AU and 1VOM biomarkers and have the features to p rove themselves as anticancer drugs. It shows strong cyt otoxicity against human lung (A-459) and breast (MC F-07) cell lines.