Perfluoroalkyl acids and thyroid hormones across stages of kidney function

Abstract Data for US adults aged ≥20 years for 2007–2012 (N = 7020) were used to study concentrations of thyroid stimulating hormone (TSH), free (FT3) and total triiodothyronine (TT3), free (FT4) total thyroxine (TT4), and thyroglobulin (TGN) across stages of glomerular function (GF). Data for 2007–2008 and 2011–2012 (N = 2549) were used to study associations between thyroid hormone biomarkers and five serum perfluoroalkyl acids (PFAAs). We report how thyroid hormone biomarkers vary in human serum across stages of GF. Stages considered were: GF-1 (normal, eGFR >90 mL/min/1.73 m2), GF-2 (60 ≤ eGFR≤90 mL/min/1.73 m2), GF-3A (45 ≤eGFR