Different volatile signals emitted by human ovarian carcinoma and healthy tissue

Many cancers are detected at a late stage resulting in high mortality rates. Thus, it is essential to develop inexpensive and simple methods for early diagnosis. Detection of different malignancies using canine scent, as well as other technical methods, has been reported in peer-reviewed journals, indicating that this may represent a new diagnostic tool for malignancies. Aim: This study aims to test the detection of different volatile organic compound signals emitted by ovarian carcinoma and normal tissues. Materials & methods: A previously tested electronic nose is used in the pilot study to analyze human grade 3 seropapillary ovarian carcinoma samples. The recorded signals were compared with healthy human Fallopian tube specimens. A variety of algorithms were tested and confusion matrices compared. In parallel, an external validation study was performed using the same type and grade of human ovarian carcinomas with healthy myometrium (first part) and postmenopausal ovarium (second part) specimens as con...