Bio-inspired Electrospun Fibre Structures - Numerical Model

A systems approach that integrates processing, structure, property and performance relations has been used in the design of multilevel-structured flbrous materials. For electrospun flbrous structure, numerical implementation of multiscale materials philosophy provides a hierarchy of computational models deflning design parameters that are integrated through computational continuum mechanics. Electrospun micro/nano (multiscale) poly("-caprolactone) (PCL) flbrous scafiolds were studied. The flbrous structures were evaluated for their mechanical, morphological and cell attachment properties. The cell attachment studies showed that cell activity on multi-scale scafiolds was higher compared to micro-flbrous scafiolds. These results suggest that the combination of a micro- and nano-flber hierarchical scafiold could be more beneflcial for tissue engineering applications than for individual scafiolds.