Evaluación de la patogenicidad en ratas del Paecilomyces lilacinus LPL-01 utilizando vías diferentes de exposición

cinus, this fungus was given using several routes of exposure (oral, pulmonary and intravenous route). In all of the assays, clinical examinations were performed daily after administration, and body weight gain of animals was evaluated. Clearance was estimated by means of collection of feces and examination of lungs and blood, depending on the route used, and ineffectiveness was evaluated by enumerating microorganisms from organs and corporal fluids in animals sacrifice at intervals. A gross necropsy of all animals was performed at interim or final sacrifice. There were no mortalities, and no evidence of pathogenicity or treatment-related toxicity either in oral or pulmonary toxicity/pathogenicity tests, without significant infection of test animals. In the intravenous toxicity/pathogenicity test, P. lilacinus caused anatomopathological changes in liver and spleen at the same period when higher infectivity was achieved. It was concluded that P. lilacinus is not pathogenic by oral and pulmonary route, but has some pathogenic effects when intravenous injection is performed.