Identification and Characterization of a Potential Ischemia-Selective N-Methyl-D-aspartate (NMDA) Receptor Ion-Channel Blocker, CNS 5788.

The identification and characterization of a potentially ischemia-selective and orally-active sulfoxide based NMDA ion-channel blocker showing good neuroprotective activity, (R)-(+)-N-(2-chloro-5-methylthiophenyl)-N'-(3-methylsulfinylphenyl)-N'-methylguanidine (CNS 5788), is described.