Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
2012
We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from D-glucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium . None of the triazole glycoconjugates tested showed activity against these microorganisms.
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