Study of Oxidative Stress and Lipid Profile in Coronary Artery Diseases

To study the role of lipid peroxidation, antioxidant status and altered lipid profile in the development of coronary artery diseases. The present study comprised of thirty clinically diagnosed cases of coronary artery diseases like angina pectoris and Myocardial Infarction (MI). Age and sex matched thirty normal individuals were studied as controls. These patients were investigated for lipid profile i.e. serum total cholestorol (TC), serum triglyceride (TG), serum low density lipoprotein (LDL) serum very low density lipoprotein (VLDL). Serum high density lipoprotein (HDL) along with blood Glutathione (GSH) level and serum malondialdehyde (MDA) levels. There was significant rise in Serum Total cholesterol, Triglycerides, LDL Cholesterol and a significant decrease in HDL Cholesterol in cases as compared to controls. There was a significant increase in serum MDA and a significant decrease in reduced glutathione in cases as compared to controls.Altered lipid profile has a potential role in the genesis of endothelial dysfunction and expression of coronary artery disease. Increased oxidative stress can result in modification of LDL to oxidized LDL that could lead to atherosclerotic lesions which is the underlying cause of coronary artery disease.