Evaluation and Modification of Goldblatt 2K1C Renovascular Hypertensive Rat Models

Objective:To establish two-kidney one-clip(2K1C) renovascular hypertensive rat model with improved Goldblatt classic hypertensive rat model.Method:Seventy male SD rats were randomly divided into two groups:modol group and sham-operation group.Left renal artery of model rats was occluded by clips from back incising.Left renal artery of control rats was liberated but not narrowed,other operation was as same as the model rats.After the operation,we evaluated results by observing blood pressure.Result:The model rats had high survival rate(94.5%) after operation.The model establishing rate was 89.1%.Compared with control rats and the results before the surgery,the blood pressure in model rats was significantly increased after 3 days of surgery and increased continuously(P0.05).Conclusion:The modification of 2K1C renovascular hypertensive models by narrowing left renal arteries by medical silk suture from back incising in rats is a simple operating and safe approach,suggesting the practical utility of this new method.