Macromolecular drug conjugates. V. Theophylline-dextran

Abstract The paper discusses some alternative ways to the synthesis of theophylline macromolecular conjugates, in which the drug is covalently linked, through a bridge to the dextran backbone. Theophylline-dextran conjugates may be obtained by two methods: (1) reaction of the drug with chloroacetylated crosslinked dextran microparticles in organic basic aprotic solvents, and (2) reaction of 7- N -chloroacetyltheophylline with crosslinked dextran microparticles in basic media. Release of theophylline from these two types of macromolecular conjugate was comparatively estimated.