Immunoreactivity of p53 nuclear protein in differentiated thyroid cancer

The study is an attempt to assess the relationship between the immunoreactivity of nuclear p53 and the classic factors predicting an unfavorable outcome of papillary thyroid cancer. Thyroid tissue from Russian and American patients with highly differentiated papillary cancer is examined. A positive immunoreactivity of p53 is detected more frequently in patients with an unfavorable prognosis (age>50 years, the presence of nondiploid DNA).