Potassium citrate slow-release micro pill and preparation method thereof

The present invention belongs to the field of pharmaceutical preparations, potassium citrate discloses a sustained-release pellets and its preparation method. The core pellets containing pellets coated extended release coating is made, wherein: the core formulation containing pellets comprising: 75-100 parts by weight of potassium citrate, 0-25 parts by weight of excipient, their sum is 100 parts by weight, or both parts an enlarged or reduced, the surfactant is 0.1-8% weight of potassium citrate and the excipients; wetting agent is potassium citrate and the weight of excipient and of 0.1 to 30%. The present invention can provide a low friability, high yield, smaller particle size, smooth surface of the core containing pellets, such pellets to facilitate further processing of the core, according to the present invention, this coating containing sustained release coated core pellets prepared citron potassium sustained release pellets, the pellets having a controllable quality, stable characteristics in vitro, in vivo with release characteristics.