Efficacy of Diabetinol™ on glycemic control in insulin resistant hamsters and subjects with impaired fasting glucose – a pilot study

Abstract The anti-diabetic potential of Diabetinol™ was tested in an animal model and in a pilot study in humans. Male Syrian golden hamsters ( n  = 18) were fed regular chow, 60% fructose or a 60% fructose diet + 1% Diabetinol™. Hamsters fed 60% fructose + 1% Diabetinol™ demonstrated a decrease in blood glucose, serum insulin, total cholesterol and triacylglycerol levels as compared to the fructose-fed animals. Efficacy of Diabetinol™ (2 × 525 mg/day) was investigated in a randomized, placebo-controlled, double-blind trial where subjects ( n  = 19) with impaired fasting glucose (IFG) on either Diabetinol™ or placebo were presented with a standard oral glucose challenge. After 84 days of supplementation a significant reduction ( p